Heme Alkylation: Drugs containing terminal double-bond olefins or triple-bond acetylenes can oxidized by CYPs to potent radical intermediates, which alkylate the prosthetic heme group and inactivate the enzyme. For example, allyl-isopropylacetamide AIA and ethinylestradiol. Covalent Binding to Apoprotein: Covalent bonding of few drugs to apoprotein causes covalent modification of protein which results in loss of catalytic activity, only if essential amino acids are modified Kamel et. This acid is corrosive, therefore some cells on the inside lining of the stomach and duodenum usually produce a natural mucus barrier which protects the lining of the stomach and duodenum. Generally there is always a balance between the acid amount that we make and the mucus protect barrier.
Peptic Ulcer Research Paper
GI-Peptic Ulcer Case Study, Case Study Example
Helicobacter pylori is a Gram-negative spiral shaped microaerophillic bacterium whose ecological niche is the human stomach. It has been seen that it colonizes over half of the world's population and is the most common bacterial infection worldwide. It is generally acquired during childhood and the infection can persist throughout the life span of the host, if untreated Evehert JE Indian population is polygenetic and is an amazing amalgamation of diverse races and cultures thus its inhabitants also differ in their genetic traits. The prevlance of gastroduodenal diseases and cancers is high in the North-eastern region of India similar to China and Japan. Till now it was believed that dietry factors are responsible for high prevalence of such gastroduodenal diseases in the North-east region because it consists of a geographically, culturally and ethnically divergent population Phukan et al
Gastric Ulcer: Consumption Of Certain Painkillers (Essay Sample)
Please join StudyMode to read the full document. Peptic Ulcer A peptic ulcer is a defect in the lining of the stomach or the first part of the small intestine, an area called the duodenum. A peptic ulcer in the stomach is called a gastric ulcer.
Unfourtonelty, these enzymes also produce chemicals that help protect the lining so when blocks the enzymes from producing chemicals it then weakens the defenses of the lining allowing an ulcer to form. Crowe and Peura, D, The last cause is not as common and is due to a tumor either cancerous or non-cancerous located in the stomach, pancreas or duodenum. Crowe and Peura, D, Common belief was that stress and spicy foods caused peptic ulcers which is false, they make the ulcer worse but do not cause it. Crowe and Peura, D,….