Background: Lactoferrin is a multipurpose protein of the transferrin domestic. It is a spherical glycoprotein with a molecular weight of about 80 kDa which is widely found in secretory discharges, such as milk, saliva, tear, and nasal secretions. Lactoferrin is also found in secondary granules of polymorphonuclear leukocytes PMN and is released by some acinar cells. It also shows antibacterial activity in vitro. The antimicrobial activity of lactoferrin is due to its ability to bind to iron and make it unavailable to bacteria.
Lactoferrin structure and functions
Lactoferrin - Wikipedia
Figure 1 shows the Haber-Weiss and Fenton reactions, which readily occur under physiological conditions with free iron and oxygen or hydrogen peroxide to produce free radicals. These free radicals will cause damage in the cell and contribute to oxidative stress 67, Iron absorption, transport, and storage are therefore highly regulated and the disruption of iron metabolism has been implicated in several diseases. The mechanism of iron absorption and transport is well known and is briefly described here. Non-heme and heme iron are absorbed into the enterocyte through DMT1 and heme carrier protein 1, respectively 5, 67,
In human tissues and organs, a balance in cell number is often maintained by a strict control of cell birth and cell loss . However, occasionally, the balance could be broken by deregulation of cell proliferation and division, which may lead to cancer. The uncontrolled cell growth is associated with several genes, known as oncogenes, which were frequently mutated or highly expressed in tumour cells . Oncogenes are mainly responsible for activating cell proliferation and enhancing tumour survival through secretion of growth factors, cell growth associated receptors, transcription factors and cell proliferation signaling pathways mediated molecules or regulating cell cycles As reviewed in this paper.
Effective date : The present invention relates to a composition comprising lactoferrin and to its use in the prevention of preterm delivery. Lactoferrin is a polypeptide with a molecular weight of approximately 80 kDa, which is a member of the transferrin protein family.